Lung Cancer - EA5231 (CLEAR)

This phase III trial compares the effect of adding AZD6738 to durvalumab versus durvalumab alone to increase time without cancer in patients with non-small cell lung cancer, following treatment with chemotherapy and surgery. AZD6738 may stop the growth of tumor cells and may kill them by blocking some of the enzymes needed for cell growth. Durvalumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Adding AZD6738 to durvalumab may increase time without cancer in patients with non-small cell lung cancer, following treatment with chemotherapy and surgery.

ClinicalTrials.gov Link: https://clinicaltrials.gov/study/NCT06732401?id=EA5231&limit=10&sort=@relevance&rank=1

Locations: Hartford Hospital, Hartford HealthCare Cancer Institute at The Hospital of Central Connecticut, MidState Medical Center, Hartford HealthCare Medical Group - Manchester, Hartford HealthCare Cancer Institute - Avon

Contacts: Krystal Myers: Krystal.Myers@hhchealth.org; Siobhan Reilly: Siobhan.Reilly@hhchealth.org